Drugline is a fortnightly electronic drug bulletin providing information on new medicines, new developments, current affairs, new indications, new PBS listings and deletions and general issues of importance to all health professionals. Click below to view the most recent volumes of Drugline.
Andexanet alfa has provisional approval for the reversal of anticoagulation in adult patients who experience life-threatening or uncontrolled bleeding with a direct factor Xa inhibitor (apixaban or rivaroxaban). Andexanet alfa is a recombinant form…
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Trastuzumab deruxtecan has been added to the Pharmaceutical Benefits Scheme (PBS) for the treatment of metastatic human epidermal growth factor receptor 2 (HER2)–positive breast cancer. Around 15-20% of all breast cancers are HER2 positive,…
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The Therapeutic Goods Administration (TGA) has published a safety alert regarding the use of high doses of baclofen. This alert has been issued following recent coronial inquiries into two deaths. Baclofen is a skeletal…
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Azacitidine tablets are now available on the Pharmaceutical Benefits Scheme (PBS) for the treatment of acute myeloid leukaemia (AML) following intensive induction chemotherapy. The safety and efficacy of azacitidine tablets in this setting was…
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The Pharmaceutical Benefits Scheme (PBS) listing for enzalutamide has recently been expanded. Enzalutamide is an oral inhibitor of androgen receptor signalling. It is now subsidised for the treatment of metastatic hormone-sensitive prostate cancer, in…
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The darolutamide product information has recently been updated to include information about hepatotoxicity. Darolutamide is a non-steroidal androgen receptor antagonist used in the treatment of prostate cancer. In the ARAMIS trial involving 1508 men…
Read moreReversing the Anticoagulant Effects of Factor Xa Inhibitors (Dec. 01 2023)
Trastuzumab Deruxtecan on the PBS (Nov. 17 2023)
Baclofen Safety Update (Nov. 03 2023)
Oral Azacitidine on the PBS (Oct. 20 2023)
Enzalutamide for Metastatic Hormone-Sensitive Prostate Cancer (Oct. 06 2023)
Darolutamide and Liver Test Abnormalities (Sep. 22 2023)
Patiromer on the Pharmaceutical Benefits Scheme (Sep. 08 2023)
Curcumin and Liver Injury (Aug. 25 2023)
Eptinezumab on the Pharmaceutical Benefits Scheme (Aug. 11 2023)
Baricitinib for Alopecia Areata (Jul. 28 2023)
A Comparison of Acalabrutinib Tablets and Capsules (Jul. 14 2023)
Migraine Prophylaxis and Pregnancy (Jun. 30 2023)
Pembrolizumab and Lenvatinib for Endometrial Cancer (Jun. 16 2023)
Apalutamide on the PBS (Jun. 02 2023)
New Boxed Warnings for JAK Inhibitors (May. 19 2023)
New Abiraterone Formulation (May. 05 2023)
Seasonal Influenza Vaccines for 2023 (Apr. 21 2023)
Ruxolitinib for Graft-Versus-Host Disease (Apr. 07 2023)
Update on Pregabalin During Pregnancy (Mar. 24 2023)
Updated Contraindications for Paxlovid™ (Mar. 10 2023)
Updated HPV Vaccine Dosing Schedule (Feb. 24 2023)
Opicapone for Parkinson’s Disease (Feb. 10 2023)
Acute Respiratory Toxicity and Hydrochlorothiazide (Jan. 27 2023)
Faricimab on the PBS (Jan. 13 2023)
Pegcetacoplan on the PBS (Dec. 30 2022)
New Formulation of Lorazepam (Dec. 16 2022)
PBAC Recommendations for COVID-19 Oral Antivirals (Dec. 02 2022)
Extended PBS Listing for Cemiplimab (Nov. 18 2022)
Vitamin B6 Supplements and Peripheral Neuropathy (Nov. 04 2022)
Decitabine With Cedazuridine (Inqovi®) (Oct. 21 2022)
Expanded PBS Listing for Pembrolizumab (Oct. 07 2022)
Niraparib on the PBS (Sep. 23 2022)
Expanded PBS Listing for Dapagliflozin (Sep. 09 2022)
New PBS Therapy for Multiple Sclerosis (Aug. 26 2022)
Longer Acting Paliperidone (Aug. 12 2022)
New Therapy for Systemic Lupus Erythematosus (Jul. 29 2022)
Indication Extension for Lenvatinib (Jul. 15 2022)
Sepsis Clinical Care Standard (Jul. 01 2022)
Clarithromycin and Electrolyte Disturbances (Jun. 17 2022)
Clozapine Safety Advisory (Jun. 03 2022)
Triple-Negative Breast Cancer Treatment (May. 20 2022)
PBS Listing Expanded for Nintedanib (May. 06 2022)
Oral COVID-19 Treatment on PBS (Apr. 22 2022)
Triple-therapy Inhaler on the PBS (Apr. 08 2022)
Gemtuzumab ozogamicin on the PBS (Mar. 25 2022)
Cardiovascular Warnings for Donepezil (Mar. 11 2022)
Levothyroxine Formulations (Feb. 25 2022)
Upadacitinib for Atopic Dermatitis (Feb. 11 2022)
Encorafenib for Colorectal Caner (Jan. 21 2022)
Safety Advisory for Pentosan Polysulfate Sodium (Jan. 07 2022)
Update on Ceftriaxone (Dec. 21 2021)
Expanded PBS Listing for Venetoclax (Dec. 10 2021)
Subcutaneous Daratumumab (Nov. 29 2021)
Triple Therapy Inhaler on the PBS (Nov. 12 2021)
Ofatumumab on the PBS (Oct. 28 2021)
Ciclosporin Eye Drops (Oct. 14 2021)
Safety Update for Anti-thyroid Drugs (Oct. 01 2021)
Cariprazine on the Pharmaceutical Benefits Scheme (Sep. 17 2021)
Alternative Adrenaline Autoinjector (Sep. 03 2021)
Post-injection Syndrome (Aug. 20 2021)
Alirocumab on the PBS (Aug. 06 2021)
Update to Empagliflozin (Jul. 23 2021)
Expanded PBS criteria for Nivolumab and Ipilimumab (Jul. 09 2021)
Triple Therapy for COPD (Jun. 24 2021)
Progesterone for Prevention of Preterm Birth (Jun. 11 2021)
Olaparib Indications Extended (May. 28 2021)
Cannabidiol for Dravet Syndrome (May. 13 2021)
PBS Changes for Adalimumab (Apr. 30 2021)
Short-course Oxycodone (Apr. 16 2021)
Ozanimod on the PBS (Mar. 31 2021)
New Dermatitis Therapy on the PBS (Mar. 19 2021)
New Asthma Therapy Listed on the PBS (Mar. 05 2021)
Updated Contraindications for Metronidazole (Feb. 17 2021)
New Therapy for Advanced Gastrointestinal Stromal Tumours (Feb. 05 2021)
Apremilast on the PBS (Jan. 22 2021)
Extended Indications for Dapagliflozin (Jan. 06 2021)
Beclometasone and Formoterol Inhaler (Dec. 23 2020)
New PBS Listing for Rivaroxaban (Dec. 11 2020)
Potential Metformin Contamination (Nov. 27 2020)
Siponimod on the PBS (Nov. 13 2020)
Expanded PBS Listing for Apomorphine (Oct. 30 2020)
Aflibercept on the PBS (Oct. 16 2020)
Lorlatinib on the PBS (Oct. 02 2020)
Removal of Bufexamac Products (Sep. 18 2020)
Acalabrutinib on the PBS (Sep. 04 2020)
Hydrochlorothiazide and Skin Cancer (Aug. 21 2020)
Zoster vaccine and immunosuppression (Aug. 07 2020)
Semaglutide on the PBS (Jul. 24 2020)
Updates to the PBS criteria for evolocumab (Jul. 09 2020)
Insulin Glargine on the PBS (May. 27 2020)
PBS Changes for Common Antibiotics (May. 13 2020)
Neuraminidase Inhibitors for Influenza (Apr. 29 2020)
National COVID-19 Guidelines (Apr. 16 2020)
Prescribing Restrictions for Hydroxychloroquine (Apr. 02 2020)
Update on Influenza Vaccines (Mar. 19 2020)
Generic Tiotropium Capsules (Mar. 05 2020)
Updated Oral and Dental Guidelines (Jan. 24 2020)
New Contraindications for Glaucoma Medication (Jan. 10 2020)
Ceftazidime with Avibactam (Dec. 27 2019)
Teduglutide for Short Bowel Syndrome (Dec. 13 2019)
Neratinib for Breast Cancer (Nov. 29 2019)
Antibiotic Awareness Week (Nov. 15 2019)
Buprenorphine Depot Injections (Nov. 01 2019)
New Warning for Febuxostat (Oct. 18 2019)
Naloxone Nasal Spray (Oct. 04 2019)
Anticoagulants in Antiphospholipid Syndrome (Sep. 20 2019)
Local Anaesthetics for Oromucosal Use (Sep. 06 2019)
Rufinamide for Lennox-Gastaut Syndrome (Aug. 23 2019)
New Treatment for Carcinoid Syndrome (Aug. 09 2019)
PBS Changes for Pembrolizumab Listing (Jul. 26 2019)
Updated Results for Pembrolizumab in treatment of metastatic non-small cell lung cancer (Jul. 12 2019)
Palbociclib added to the Pharmaceutical Benefits Scheme (Jun. 28 2019)
Faster-Acting Insulin Aspart (Jun. 14 2019)
Alemtuzumab Safety Review (May. 31 2019)
Safinamide for Parkinson’s Disease (May. 17 2019)
Updated Recommendations for Measles Vaccination (May. 03 2019)
New High-Strength Insulin (Apr. 18 2019)
Tofacitinib Safety Issue (Apr. 05 2019)
New Medication for Weight Management (Mar. 22 2019)
Carbimazole Safety Issues (Mar. 08 2019)
Updated Recall Procedures (Feb. 22 2019)
Appropriate Use of Promethazine (Feb. 08 2019)
New Contraindication for Doxycycline (Jan. 25 2019)
Ertugliflozin for Type 2 Diabetes (Jan. 11 2019)
Pholcodine and Anaphylaxis (Dec. 14 2018)
