A generic tiotropium capsule has recently been added to the Pharmaceutical Benefits Scheme (PBS). Braltus® capsules are considered equivalent to Spiriva® capsules for the purposes of brand substitution on the PBS. However, some important differences should be noted to avoid confusion.

Braltus® capsules for inhalation contain 13 micrograms of tiotropium, while Spiriva® contains 18 micrograms per capsule. However, the dose delivered from the mouthpiece of the inhaler device is 10 micrograms per capsule for each brand. Braltus® is able to provide the same delivered dose from a smaller formulated dose due to the enhanced aerosolisation properties of the formulation.

Braltus® capsules should only be administered using the Zonda® inhaler device included in each pack. While the Zonda® device is operationally similar to the Spiriva® HandiHaler® device, the devices are not interchangeable. Patients should be educated on proper inhaler technique for each device they use.

A comparison of the two brands of tiotropium capsules is shown below.

  Braltus® Spiriva®
Active ingredient Tiotropium (as bromide) Tiotropium (as bromide monohydrate)
Tiotropium per capsule 13mcg 18mcg
Tiotropium delivered dose per capsule 10mcg
Recommended dose 1 capsule inhaled daily
Indications Long-term maintenance treatment of bronchospasm and dyspnoea associated with COPD; prevention of COPD exacerbations
Device Zonda® HandiHaler®
Device maintenance Discard device after 30 uses. New device supplied with each pack. Device can be washed and re-used
Presentation Bottle, clear capsules Blister pack, green capsules


  1. Algorta J, Andrade L, Medina M, Kirkov V, Arsova S, Li F, et al. Pharmacokinetic bioequivalence of two inhaled tiotropium bromide formulations in healthy volunteers. Clin Drug Investig. 2016; 36(9): 753-62.
  2. Braltus® (Tiotropium) Australian approved product information. Macquarie Park: Teva Pharma. Approved October 2018.
  3. Therapeutic Goods Administration. Australian Public Assessment Report for Tiotropium: Braltus®. Woden: TGA; 2019.

Subscribe Knowledge Centre Updates

Enter your details to receive Knowledge Centre updates