Safety Notice – Adrenaline Aguettant 1:10,000 (1 mg / 10 mL) PFS

There is a supply disruption of the Adrenaline Aguettant 1:10,000 (1 mg / 10 mL) pre-filled syringe that is expected to last until 15^th August 2024. There is an alternate TGA registered pre-filled syringe available, Adrenaline Link 1:10,000 (1 mg / 10 mL), however there are a few differences between the products (see table below). Supply of Adrenaline Aspen 1:10,000 (1 mg / 10 mL) ampoules remain available.

Connector Compatibility
Adrenaline pre-filled syringes may be administered through a connector valve which are used to connect peripheral and central vascular access devices to IV lines. Not all connectors are compatible with Link’s glass syringe and reports of blocked syringes have been reported. To ensure patient safety, ensure that a compatible connector is used. Listed below are the compatible valve connectors for the two products (as per information provided by Juno Pharmaceuticals and Link Healthcare):

Recommendations
Please discuss with your clinical coordinators to ensure that hospital staff are informed of the differences and determine which compatible connectors are available and stored with the pre-filled syringe. Ensure that a safety notice is kept with the adrenaline pre-filled syringes until supply disruption is resolved.

Where the adrenaline ampoules are used users need to be aware of the risk of injury due to their presentation in a glass ampoule and the requirements for drawing up doses in a timely manner for emergency situations. If utilising smaller quantities for resuscitation trays or emergency trolleys, clinicians should consider the need to protect individual ampoules from light.

Retain this notice in a prominent position, including in other related business units until supplies return to normal. Report any problems identified with medicines, vaccines or medical devices to the TGA.

Should you require further information regarding this matter, please contact Juno Pharmaceuticals on (03) 8888 1288, or your pharmacist at HPS Pharmacies.

List of differences between Adrenaline pre-filled syringes and compatible connectors

Adrenaline Aguettant	Adrenaline Link
Polypropylene syringe	Glass syringe
Notable excipients: None	Notable Excipients: Sodium metabisulfite

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