HPS Pharmacies wish to advise that Pfizer, in consultation with the Therapeutic Goods Administration (TGA), has communicated a change in reconstitution time for Zavicefta® as follows:

Zavicefta® InjectionCeftazidime/avibactam 2000/500 mgARTG 301205

The reconstitution time for Zavicefta® has changed from three minutes to up to four minutes. This slight increase is due to a small change in the particle size distribution of the active ingredients.

The manufacturer advises that Zavicefta® vials are to be reconstituted with 10mL sterile Water for Injection, before being further diluted with an appropriate IV buffer. The product information should be reviewed for full reconstitution and administration instructions.

Retain this notice in a prominent position, including in other related business units for one month. Report any problems identified with medicines, vaccines or medical devices to the TGA.

Should you require further information regarding this matter, please contact Pfizer on 1800 675 229 or your pharmacist at HPS Pharmacies.

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